Antibiotic Manufacturing Process Segregation Project
Pharmaceutical Manufacturer, PA

• Detailed Design
• Procurement
• Start-up
• Validation
• Construction Management

• Process segregation
• Relocation and demolition of existing facilities
• Design of glove boxes
• Installation of drum washer
• Design of an air lock segregation room
• Design of pressure transmitter and isolation valves
• Decontamination of non-antibiotic process areas
• Segregation of HVAC systems
• Design of HEPA filters and exhaust monitoring
• Area pressurization monitoring   

• Completed numerous process blower and HEPA filter replacements and process filter and equipment relocations
• Conducted pump replacements and relocations
• Installed glove box for clean product feeds into process vessels
• Performed utility relocations for nitrogen, water, DI water, plant air, and breathing air
• Conducted structural and architectural modifications/construction for decontamination clean room and segregation area
• Completed numerous process blower, filter and vent replacements
• Installed Level 3 containment system for sampling process products and vessels
• Updated process control system for automated operations and monitoring
• Installed controls on DI water system to prevent backflow from antibiotic sources
• Installed controls on nitrogen system to prevent backflow from potentially high-pressure antibiotic sources
• Sealed wall penetrations to prevent migration of antibiotic compounds to adjacent areas
• Installed door alarms and beacon lights as necessary to limit personnel access and prevent the migration of antibiotic compounds to adjacent areas  

  Return to Project listing